The New York Yankees will look to even their weekend interleague series with the Philadelphia Phillies when they meet on Saturday afternoon. The Phillies cruised to a 12-5 in in Friday’s series opener. The Phillies (59-44) will send left-hander Ranger Suarez (7-4, 2.66 ERA) to the mound, while the Yankees (56-47) counter with right-hander Marcus Stroman (2-1, 5.64 ERA).
First pitch from Yankee Stadium in New York is set for 1:05 p.m. ET. Philadelphia is -129 on the money line (risk $129 to win $100) in the latest Phillies vs. Yankees odds from DraftKings Sportsbook, while New York is a +109 underdog (risk $100 to win $109). The over/under for total runs scored is 9. Before making any Yankees vs. Phillies picks, be sure to see the MLB predictions from SportsLine’s model. Also be sure to see the model’s longshot MLB picks for Saturday, picks for Guardians vs. Royals, top MLB props and top home-run picks.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 17 of the 2025 MLB season 46-43 on top-rated MLB betting picks. It has excelled in making home run prop picks, returning more than 40 units of profit. Anybody following at sportsbooks and on betting apps, could have seen strong returns. New users can also take advantage of the latest DraftKings promo code to get $150 in bonus bets when they bet $5. Claim that offer here.
Here are the model’s best bets for Yankees vs. Phillies (odds subject to change):
- Yankees ML (+109)
- Aaron Judge, Yankees, over 1.5 total bases (-112) (void — Judge is out of the lineup with an elbow issue)
Yankees to win (+109)
Though Philadelphia won Game 1, New York has dominated the series overall of late, winning seven of the past nine matchups, including four of the last six at Yankee Stadium. The Yankees have also had a lot of success on their home field, going 30-20 there this season. The Phillies, meanwhile, are just 26-25 on the road in 2025. The model favors New York, which has a money line probability of well over 50%.
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